Journal ID (nlm-ta): PLoS Pathog
Journal ID (iso-abbrev): PLoS Pathog
Journal ID (publisher-id): plos
Journal ID (pmc): plospath
Title:
PLoS Pathogens
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1553-7366
ISSN
(Electronic):
1553-7374
Publication date
(Electronic):
29
November
2016
Publication date Collection:
November
2016
Volume: 12
Issue: 11
Electronic Location Identifier: e1006026
Affiliations
[1
]Graduate Program in Bioinformatics and Systems Biology, University of California San
Diego, La Jolla, California, United States of America
[2
]San Diego VA medical Center and Veterans Medical Research Foundation, San Diego, California,
United States of America
[3
]Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton,
Southampton, Hampshire, United Kingdom
[4
]Department of Medicine, University of California San Diego, La Jolla, California,
United States of America
[5
]Division of Microbiology and Immunology, Department of Pathology, University of Utah
School of Medicine, Salt Lake City, Utah, United States of America
[6
]Department of Pathology, University of California San Diego, La Jolla, California,
United States of America
[7
]UNC HIV Cure Center, Department of Medicine, Microbiology and Immunology, University
of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Emory University, UNITED STATES
Author notes
DDR has consulted for Chimerix, Gilead, Antiva, Monogram and the HIV Immunotherapeutics
Institute. All other authors have declared that no competing interests exist.
-
Conceptualization: CHWh BM NBB LJM CAS DMM DDR VP AB CHWo.
-
Data curation: CHWh BM AB CHWo.
-
Formal analysis: CHWh BM AB CHWo.
-
Funding acquisition: CAS DMM DDR VP AB CHWo.
-
Investigation: CHWh BM AB CHWo.
-
Methodology: CHWh BM NBB AB CHWo.
-
Project administration: AB CHWo.
-
Resources: CAS DMM DDR VP AB CHWo.
-
-
-
Validation: CHWh BM NBB AB CHWo.
-
Visualization: CHWh BM AB CHWo.
-
Writing – original draft: CHWh AB CHWo.
-
Writing – review & editing: CHWh BM NBB LJM CAS DMM DDR VP AB CHWo.
[¤]
Current address: Department of Microbiology, Immunology and Tropical Medicine, School
of Medicine and Health Sciences, George Washington University, Washington DC, United
States of America
‡ These senior authors contributed equally to the manuscript.
Author information
Article
Publisher ID:
PPATHOGENS-D-16-01341
DOI: 10.1371/journal.ppat.1006026
PMC ID: 5127598
PubMed ID: 27898737
SO-VID: f7d6044a-f939-4c91-b7b0-3ab034d87df1
Copyright © © 2016 White et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: AI096113
Award Recipient
:
ORCID: http://orcid.org/0000-0001-5714-0002
David M. Margolis
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: AI096113
Award Recipient
: Douglas R Richman
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: AI096113
Award Recipient
:
Vicente Planelles
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: AI096113
Award Recipient
:
ORCID: http://orcid.org/0000-0002-7211-9751
Celsa A. Spina
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: AI096113
Award Recipient
:
Christopher H. Woelk
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: P30 AI36214
Award Recipient
: Douglas R Richman
Funded by: funder-id http://dx.doi.org/10.13039/100000865, Bill and Melinda Gates Foundation;
Award ID: OPP1045955
Award Recipient
:
ORCID: http://orcid.org/0000-0002-8800-2160
Alberto Bosque
Funded by: funder-id http://dx.doi.org/10.13039/100009012, Veterans Affairs San Diego Healthcare System;
Award ID: BX001160
Award Recipient
:
ORCID: http://orcid.org/0000-0002-7211-9751
Celsa A. Spina
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: AI080193
Award Recipient
: Douglas R Richman
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: AI104282
Award Recipient
:
Christopher H. Woelk
Funded by: Veterans Affairs Office of Research and Development
Award ID: BX007080
Award Recipient
: Cory Haley White
Funded by: funder-id http://dx.doi.org/10.13039/100007496, Biomedical Laboratory Research and Development, VA Office of Research and Development;
Award ID: BX007080
Award Recipient
:
Nadejda Beliakova-Bethell
This work was performed with the support of the Collaboratory of AIDS Researchers
for Eradication (CARE), a Martin Delaney Collaboratory funded through a National Institutes
of Health grant (AI096113) to DMM, DDR, VP, CAS and CHWo; by the UCSD Center for AIDS
Research from the National Institutes of Health to DDR (P30 AI36214); by a grant from
the Bill & Melinda Gates Foundation through the Grand Challenges Explorations initiative
to AB (OPP1045955); and a Veterans Affairs grants (BX001160 and BX007080) to CAS and
NBB, respectively; as well as other National Institutes of Health grants to DRR (AI080193)
and to CHWo (AI104282). The views expressed here are those of the authors and do not
necessarily reflect the position or policy of the Veterans Affairs or the United States
government. The funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
HIV-1
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Gene Expression
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Virology
Subject:
Viral Persistence and Latency
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Blood Cells
Subject:
White Blood Cells
Subject:
T Helper Cells
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Helper Cells
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Helper Cells
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Cells
Subject:
White Blood Cells
Subject:
T Helper Cells
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Virology
Subject:
Viral Replication
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Immunodeficiency Viruses
Subject:
HIV
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Retroviruses
Subject:
Lentivirus
Subject:
HIV
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Gene Expression
Subject:
Viral Gene Expression
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Microbial Genetics
Subject:
Viral Genetics
Subject:
Viral Gene Expression
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Virology
Subject:
Viral Genetics
Subject:
Viral Gene Expression
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Vaccination and Immunization
Subject:
Antiviral Therapy
Subject:
Antiretroviral Therapy
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Vaccination and Immunization
Subject:
Antiviral Therapy
Subject:
Antiretroviral Therapy
Subject:
Medicine and Health Sciences
Subject:
Public and Occupational Health
Subject:
Preventive Medicine
Subject:
Vaccination and Immunization
Subject:
Antiviral Therapy
Subject:
Antiretroviral Therapy