Modifications of the Striatal Dopamine Metabolism during the Estrus Cycle in Mice

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Abstract

The metabolism of striatum dopamine (DA) was studied in mice during proestrus, estrus and diestrus. The following results have been obtained: (1) the concentration of DA is higher in diestrus than in proestrus and estrus; (2) the concentration of its metabolite, homovanillic acid (HVA), is maximum in the estrus phase; (3) the DA turnover, evaluated by measuring the DA disappearance after blocking synthesis with methyl-tyrosine, is faster in estrus than in the other phases. These results have been discussed in view of the possible role of dopaminergic mechanisms in the control of gonadotropin secretion.

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Journal

Journal ID (publisher-id): NEN

Journal ID (nlm-ta): Neuroendocrinology

Journal ID (doi): 10.1159/issn.0028-3835

Title: Neuroendocrinology

Publisher: S. Karger AG

ISSN (Print): 0028-3835

ISSN (Electronic): 1423-0194

Publication date Subscription-year: 1976

Publication date (Print): 1976

Publication date (Electronic): 25 March 2008

Volume: 21

Issue: 3

Pages: 262-266

Affiliations

Istituto di Ricerche Farmacologiche ‘Mario Negri’, Milano

Article

Publisher ID: 122531 Other ID: Neuroendocrinology 1976;21:262–266

DOI: 10.1159/000122531

PubMed ID: 1035408

SO-VID: f7ee0244-65b9-4565-a8bd-b13bb3019462

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 11 September 1975

Date accepted : 28 July 1976

Page count

Pages: 5

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