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Autophagy in the pathogenesis of disease.

Cell

Aging, physiology, Oxidative Stress, ultrastructure, metabolism, Lysosomes, Humans, Homeostasis, Genomic Instability, etiology, Disease, Cell Survival, Cell Death, genetics, Autophagy, Animals

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      Abstract

      Autophagy is a lysosomal degradation pathway that is essential for survival, differentiation, development, and homeostasis. Autophagy principally serves an adaptive role to protect organisms against diverse pathologies, including infections, cancer, neurodegeneration, aging, and heart disease. However, in certain experimental disease settings, the self-cannibalistic or, paradoxically, even the prosurvival functions of autophagy may be deleterious. This Review summarizes recent advances in understanding the physiological functions of autophagy and its possible roles in the causation and prevention of human diseases.

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      Journal
      18191218
      10.1016/j.cell.2007.12.018
      2696814

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