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      Compensatory Adrenal Growth is Neurally Mediated

      ,

      Neuroendocrinology

      S. Karger AG

      Unilateral adrenalectomy, Adrenal nerves, Rats, Unilateral hypothalamic lesions

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          Abstract

          We have tested the possibility that compensatory adrenal growth is neurally mediated. Small unilateral electrolytic lesions were made in the ventral hypothalamus of young male rats. Subsequently, unilateral adrenalectomy was performed on the side ipsilateral or contralateral to the hypothalamic lesion. Four days later the animals were killed and the remaining adrenal was weighed; the location and extent of the hypothalamic lesions were determined. Lesions placed on the same side as adrenalectomy prevented compensatory growth of the remaining gland (p < 0.005), while lesions on the side opposite to the removed adrenal did not interfere with compensatory adrenal growth. We conclude from these findings, and from a review of some anatomical studies, that compensatory adrenal growth is effected through a reflex that involves both afferent and efferent neural limbs.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1975
          1975
          20 March 2008
          : 19
          : 4
          : 352-362
          Affiliations
          Department of Physiology, University of California, San Francisco, Calif.
          Article
          122456 Neuroendocrinology 1975;19:352–362
          10.1159/000122456
          1226228
          © 1975 S. Karger AG, Basel

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          Page count
          Pages: 11
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          Paper

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