14
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Half abdomen tumor – giant retroperitoneal lipoma: a case report and review of the literature

      case-report

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The pure retroperitoneal lipoma is a sporadic benign tumor originating from the mesenchymal tissue. There are only a few data in the literature. The technique available at this moment cannot establish a clear distinction between a benign adipose mass and a low-grade liposarcoma. This study presents the case of a 53-year-old man presenting computed tomography (CT) and magnetic resonance imaging (MRI) findings that revealed a giant retroperitoneal fatty tumor of 365/210/165 mm dimensions, suspected of malignancy. The patient’s medical history, clinical data, and blood tests are more likely inclined to a benign condition. Liposarcoma couldn’t be excluded preoperatively. The patient underwent an open surgical procedure respecting the oncological principles, with complete resection of 6400 g of retroperitoneal adipose tumor that also affected the surrounding organs’ normal abdominal anatomy. The tumor was relatively well delimited without any signs of local invasion or infiltration. Three solid masses described on the MRI were identified upon dissection and sent separately for histological examination. The result indicated a giant retroperitoneal lipoma with benign characteristics. Facing imagistic difficulties to distinguish lipoma from liposarcoma clearly, and the inconclusiveness of fine-needle biopsies, oncological resection remains the only option as a diagnostic method and curative treatment.

          Related collections

          Most cited references46

          • Record: found
          • Abstract: found
          • Article: not found

          Cellular and molecular features of lipoma tissue: comparison with normal adipose tissue.

          Involvement of adipose-derived stem/progenitor/stromal cells (ASCs) in the development of lipomas has been suggested, but the pathogenesis and pathophysiology of this tumour remain unclear.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Posttraumatic lipoma: fact or fiction?

            Both trauma and lipomas are a common occurrence in surgical practice. Lipomas are usually benign adipose tumors with as-yet unexplained pathogenesis and etiology. A link between soft tissue trauma and the formation of lipomas has been described, with the latter being named posttraumatic lipomas. Twenty-three cases of posttraumatic lipomas in 19 patients treated at our institution between August 2001 and January 2005 were reviewed with regard to medical history, magnetic resonance imaging findings, intraoperative findings, clinical chemistry, and histology. The mean age of the patients was 50.0 years (+/-15.5). The average time between soft tissue trauma and lipoma formation was 2.6 years (range, 0.5-6.0 years). Sixteen of the 19 patients reported extensive and slowly resolving hematoma formation after the traumatic event. Nine of 23 lipomas were found on the upper extremities, 3 on the lower extremities, 9 on the trunk, and 2 on the face. All tumors were located epifascially. Twenty-two lipomas were removed by simple excision and, in one case, aspiration lipectomy was performed. Pathology demonstrated capsulated and noncapsulated benign adipose tumors in 23 cases. The average body mass index, amounted to 30 kg/m(2) (+/-7.6 kg/m(2)). Seven patients without known bleeding disorders presented with an elevated partial thromboplastin time. The pathogenetic link between soft tissue trauma and the formation of posttraumatic lipomas is still controversially discussed. There are 2 potential explanations to correlate soft tissue trauma and adipose tissue tumor growth. The first is the formation of so-called posttraumatic pseudolipomas by prolapsing adipose tissue through fascia resulting from direct impact. A second possibility points toward lipoma formation as a result of preadipocyte differentiation and proliferation mediated by cytokine release following soft tissue trauma and hematoma formation.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Non-symmetric subcutaneous lipomatosis associated with familial combined hyperlipidaemia.

              A family with familial combined hyperlipidaemia in which affected members had nonsymmetric subcutaneous lipomatosis (NSSCL) is described. Affected members had high serum levels of total cholesterol, low density lipoprotein (LDL) cholesterol and high density lipoprotein (HDL) cholesterol. By contrast, family members without NSSCL had normal lipid levels. There was also a correlation between the degree of hyperlipidaemia and the amount of subcutaneous lipomas. The occurrence of hyperlipidaemia in family members with NSSCL suggests the existence of a genetic linkage between these two characteristics, but did not show any association with HLA haplotyping. To our knowledge this association between lipid abnormalities and NSSCL has not been previously reported.
                Bookmark

                Author and article information

                Journal
                Rom J Morphol Embryol
                Rom J Morphol Embryol
                RJME
                Romanian Journal of Morphology and Embryology
                Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest
                1220-0522
                2066-8279
                Jan-Mar 2022
                04 August 2022
                : 63
                : 1
                : 237-244
                Affiliations
                [1 ]Department of Urology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
                [2 ]Department of Urology, Prof. Dr. Theodor Burghele Clinical Hospital, Bucharest, Romania
                [3 ]Department of Obstetrics, Gynecology and Neonatology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
                [4 ]Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, Romania
                Author notes
                Corresponding Author: Răzvan-Ionuţ Popescu Assistant Professor, MD, PhD Student, Department of Urology Carol Davila University of Medicine and Pharmacy 8 Eroii Sanitari Avenue, Sector 5 050474 Bucharest Romania +4072–492 823 razvan-ionut.popescu@ 123456drd.umfcd.ro
                Corresponding Author: Costin Berceanu Associate Professor, MD, PhD, Department of Obstetrics and Gynecology University of Medicine and Pharmacy of Craiova Emergency County Hospital of Craiova 2 Petru Rareş Street 200349 Craiova, Dolj County Romania +40722–728 180 dr_berceanu@ 123456yahoo.com
                Article
                630122237244
                10.47162/RJME.63.1.27
                9593116
                36074690
                f80f83a6-7af4-4f6c-8b6b-015758de46e5
                Copyright © 2020, Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest

                This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.

                History
                : 30 April 2022
                : 04 August 2022
                Categories
                Case Report

                giant retroperitoneal lipoma,rare tumor,benign adipose tumor,adipocyte stem cell

                Comments

                Comment on this article