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      VEGF in Signaling and Disease: Beyond Discovery and Development

      , ,
      Cell
      Elsevier BV

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          Abstract

          The discovery of vascular endothelial-derived growth factor (VEGF) has revolutionized our understanding of vasculogenesis and angiogenesis during development and physiological homeostasis. Over a short span of two decades, our understanding of the molecular mechanisms by which VEGF coordinates neurovascular homeostasis has become more sophisticated. The central role of VEGF in the pathogenesis of diverse cancers and blinding eye diseases has also become evident. Elucidation of the molecular regulation of VEGF and the transformative development of multiple therapeutic pathways targeting VEGF directly or indirectly is a powerful case study of how fundamental research can guide innovation and translation. It is also an elegant example of how agnostic discovery and can transform our understanding of human disease. This review will highlight critical nodal points in VEGF biology including recent developments in immunotherapy for cancer and multi-target approaches in neovascular eye disease.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          00928674
          March 2019
          March 2019
          : 176
          : 6
          : 1248-1264
          Article
          10.1016/j.cell.2019.01.021
          6410740
          30849371
          f81b1ea4-9d21-4832-96b4-c0f35efd270c
          © 2019

          https://www.elsevier.com/tdm/userlicense/1.0/

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