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      Alendronate retards the progression of lumbar intervertebral disc degeneration in ovariectomized rats.

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          Abstract

          Increasing evidence has revealed a positive correlation between postmenopausal osteoporosis and intervertebral disc degeneration, the underlying mechanism of which might be associated with changes in the vertebral bone and endplate. Alendronate (ALN) can increase bone mass and improve the microstructure of osteoporotic vertebrae, which might be helpful in preserving disc morphology and mechanical properties. This study aims to investigate the effects of ALN on lumbar intervertebral disc degeneration related to osteoporosis using an ovariectomized (OVX) rat model.

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          Author and article information

          Journal
          Bone
          Bone
          Elsevier BV
          1873-2763
          1873-2763
          Aug 2013
          : 55
          : 2
          Affiliations
          [1 ] Department of Orthopedic Surgery, Hebei Medical University, Shijiazhuang, China.
          Article
          S8756-3282(13)00105-1
          10.1016/j.bone.2013.03.002
          23500174
          f82a930c-3bbe-44c9-b0d9-9e72921cc7e9
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