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      Predictors of Sudden Cardiac Death for Patients with Chagas’ Disease: A Hospital-Derived Cohort Study

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          Abstract

          This study was carried out to identify patients with Chagas’ disease at risk of sudden cardiac death, inasmuch as such patients have not been recognized thus far. Seventy-four consecutive patients with a positive complement fixation test for Chagas’ disease prospectively followed up at the Cardiomyopathy Clinic from January 1990 to June 1993 were entered into the study. Patients underwent medical history, physical examination, serological tests, resting electrocardiography, chest X-ray and two-dimensional echocardiography. Eighteen of 74 (24%) patients died during the study period, 8 (10%) suddenly and 10 (14%) from pump failure. Sudden death comprised 44% of total deaths. In the univariate model, cardiomegaly in the chest X-ray, left ventricular systolic and diastolic dimension, left ventricular ejection fraction, left atrial dimension and apical aneurysm as detected echocardiographically, and systolic blood pressure were associated with sudden cardiac death. In the multivariate model, however, apical aneurysm and left ventricular diastolic dimension were retained as predictors of sudden cardiac death. We conclude that chagasic patients with apical aneurysm and left ventricular dilation are at risk of sudden cardiac death.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1996
          1996
          19 November 2008
          : 87
          : 6
          : 481-487
          Affiliations
          Department of Internal Medicine, Faculty of Medicine of Triângulo Mineiro, Uberaba, and Heart Institute of Santa Casa Hospital, Ribeirão Preto, Brazil
          Article
          177142 Cardiology 1996;87:481–487
          10.1159/000177142
          8904674
          © 1996 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Categories
          General Cardiology

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