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Abstract
Colloid carcinoma (CC) of the pancreas is a histopathological variant of ductal adenocarcinoma,
which is characterised by the presence of large pools of extracellular mucin, containing
neoplastic cells. The mucin component comprises at least 50% of CC (according to the
definition by the World Health Organization) or at least 80% of the tumour (according
to the US Armed Forces Institute of Pathology). In the vast majority of cases, CC
develop from pre-existing intraductal papillary mucinous neoplasms, especially those
forming intestinal-type papillae and characterised by MUC2 expression. Data concerning
the long-term prognosis in patients with CC are discrepant. In this review, the authors
present contemporary definitions of CC, issues of its epidemiology, symptomatology,
pre-operative diagnostics, histopathology, treatment and prognosis. Special attention
has been paid to pathogenesis of CC.