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      Compartmental changes in expression of c-Fos and FosB proteins in intact and dopamine-depleted striatum after chronic apomorphine treatment.

      Brain Research

      Animals, Apomorphine, pharmacology, Behavior, Animal, drug effects, physiology, Calbindins, Corpus Striatum, chemistry, enzymology, Denervation, Dopamine, deficiency, Dopamine Agonists, Dyskinesia, Drug-Induced, physiopathology, Male, Nerve Tissue Proteins, analysis, Neuronal Plasticity, Oxidopamine, Proto-Oncogene Proteins c-fos, biosynthesis, Rats, Rats, Wistar, S100 Calcium Binding Protein G, Sympatholytics

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          Abstract

          Chronic administration of dopaminergic agonists to rats with unilateral 6-OH-dopamine (6-OHDA) lesions of nigrostriatal pathway produces behavioral sensitization to subsequent agonist challenges and may serve as a model for DOPA-induced dyskinesias. In order to understand striatal mechanisms behind this long-term behavioral change we examined striatal c-Fos and FosB immunoreactivity induced by apomorphine challenge (5 mg/kg, s.c.) after 3 days of withdrawal following a 2-week administration (5 mg/kg, b.i.d., s.c.) both in intact and 6-OHDA-lesioned animals. In intact rats, c-Fos induction by acute apomorphine exposure showed a striosomal pattern, whereas FosB immunopositivity was diffusely distributed. Following chronic administration, FosB induction turned to a clear striosome dominant pattern similar to c-Fos expression. In denervated striatum, expression of both proteins was profoundly augmented in a homogeneous pattern after a single dose of apomorphine. A distinct striosomal patterning appeared after chronic apomorphine administration in ventromedial part of the denervated striatum with a down-regulation in the matrix and relative enhancement in striosomes. These results suggest that compartmental reorganization of striatal neuronal activity may play a role in long-term behavioral changes induced by chronic dopaminergic treatments both under normal and dopamine-depleted conditions. Copyright 1999 Elsevier Science B.V.

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          10216178

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