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      Disturbances of trace element metabolism in ESRD patients receiving hemodialysis and hemodiafiltration

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          Abstract

          Introduction

          Accumulation of trace elements occurs in conditions of decreased kidney function. In some conditions, increased trace elements can have toxic features. On the other hand, studies are showing that concentration of some trace elements could be decreased in ERSD patients as well. The most important factor affecting trace element concentration in ERSD patients is the degree of renal failure and the usage of replacement therapy.

          Materials and methods

          We analyzed the trace elements’ (boron, aluminum, vanadium, chromium, manganese, cobalt, nickel, copper, zinc, arsenic, selenium, rubidium, strontium, cadmium, cesium, barium and lead) concentration in the whole blood of 41 ESRD patients who were treated with hemodialysis and hemodiafiltration and also of 61 healthy blood donors. In addition, comparison of trace element blood levels of patients receiving hemodialysis and hemofiltration was carried out. Whole blood trace element concentration was determined using inductive coupled plasma mass-spectrometry (ICPMS).

          Results

          Levels of boron, aluminum, vanadium, chromium, manganese, zinc, strontium, cadmium, barium and lead were significantly increased in ESRD patients. Significantly decreased levels were observed for nickel, arsenic, selenium and rubidium. Blood levels of cobalt, copper, cadmium and lead in hemodialysis patients were significantly higher compared to patients receiving hemodiafiltration.

          Conclusions

          ESRD is accompanied with serious and multidirectional changes of trace element blood levels. The highest degree of blood level increases were observed for nonessential and toxic trace elements. Disorders of essential trace elements were manifested in a minor degree. Besides this, there were observed differences of trace element concentrations between ESRD patients receiving hemodialysis and hemo-diafiltration.

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          Author and article information

          Journal
          Cent European J Urol
          Cent European J Urol
          CEJU
          Central European Journal of Urology
          Polish Urological Association
          2080-4806
          2080-4873
          19 December 2013
          2013
          : 66
          : 4
          : 472-476
          Affiliations
          [1 ]Medved's Research Center of Preventive Toxicology, Food and Chemical Safety, Ministry of Health Ukraine, Kyiv, Ukraine
          [2 ]Centre for Clinical Toxicology of National Child Specialized Clinic “Ohmatdyt” Ministry of Health, Ukraine, Kyiv, Ukraine
          [3 ]Institute of Nephrology at the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
          Author notes
          Correspondence Oleksii Makarov, Medved's Research Center of Preventive Toxicology, Food and Chemical Safety, Ministry of Health Ukraine, 6, Heroiv Oborony Street, 03680 Kyiv, Ukraine. phone: +38 050 446 9075. olemakar@ 123456gmail.com
          Article
          00307
          10.5173/ceju.2013.04.art23
          3992448
          24757548
          Copyright by Polish Urological Association

          This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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