Increased oxidative stress is related to disease severity in the ALS motor cortex: A PET study.

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Abstract

To investigate cerebral oxidative stress based on an over-reductive state caused by mitochondrial dysfunction and its relationship to disease severity in patients with amyotrophic lateral sclerosis (ALS) using PET with [(62)Cu]diacetyl-bis(N(4)-methylthiosemicarbazone) ((62)Cu-ATSM).

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Journal

Journal ID (iso-abbrev): Neurology

Title: Neurology

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1526-632X

ISSN (Print): 0028-3878

Publication date (Electronic): May 19 2015

Volume: 84

Issue: 20

Affiliations

[1 ] From the Second Department of Internal Medicine, Faculty of Medical Sciences (M.I., A.M., O.Y., T.H., Y.N.), and Biomedical Imaging Research Center (H.O., T.T., T.M., Y.K., M.Y.), University of Fukui; and Faculty of Nursing and Social Welfare Sciences (M.Y.), Fukui Prefectural University, Japan.

[2 ] From the Second Department of Internal Medicine, Faculty of Medical Sciences (M.I., A.M., O.Y., T.H., Y.N.), and Biomedical Imaging Research Center (H.O., T.T., T.M., Y.K., M.Y.), University of Fukui; and Faculty of Nursing and Social Welfare Sciences (M.Y.), Fukui Prefectural University, Japan. myoneda@fpu.ac.jp.

Article

Publisher Item ID: WNL.0000000000001588

DOI: 10.1212/WNL.0000000000001588

PubMed ID: 25904686

SO-VID: f854fcbf-e01d-430a-86c8-91f4a071e4e7

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