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      Self-assembly of DNA-based Nanomaterials and Potential Application in Drug Delivery.

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          Abstract

          DNA can be self-assembled into programmable two-dimensional and three-dimensional nanoarchitectures with arbitrarily predetermined sizes and shapes. Because of the addressable arbitrary size and shape, great capacity of cargo loading, ability to be internalized by cells, the stability of structures under physiological conditions and excellent biocompatibility, the pristine DNA nanostructures are explored as drug vehicles in drug delivery. In addition, DNA block copolymer and DNADendron hybrid, as new building blocks, can be self-assembled into different kinds of ordered structures, e.g., nanofibers, spherical micelles, and vesicles, in aqueous solution. Recent studies have shown that some of these nanostructures could easily enter cells with excellent cell uptake efficiency. Herein, this review will mainly introduce the self-assembly behavior of pristine DNA and DNA hybrid materials including DNA block copolymers and DNA-Dendron hybrids, and their application in drug delivery.

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          Author and article information

          Affiliations
          [1 ] The State Key Laboratory of Refractories and Metallurgy, School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology, Wuhan, China.
          [2 ] School of Chemistry and Chemical Engineering, Wuhan University of Science and Technology Wuhan, China.
          Journal
          Curr Top Med Chem
          Current topics in medicinal chemistry
          Bentham Science Publishers Ltd.
          1873-4294
          1568-0266
          2017
          : 17
          : 16
          27875975 10.2174/1568026617666161122121142 CTMC-EPUB-79872

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