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      Clinical utility of ozone therapy for musculoskeletal disorders

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          Abstract

          Oxygen-ozone (O 3) therapy serves as an alternative medical technique that increases the oxygen in the body along with the introduction of O 3. O 3 therapy has finally reached a level where the biological mechanisms of action have been understood, showing that they are in the domain of physiology, biochemistry, and pharmacology. Few clinical applications have been reviewed here as well as exemplifying that O 3 therapy is particularly useful in musculoskeletal disorders. In the therapeutic range, O 3 can be used as a more effective and safe substitute of standard medications. O 3 therapy has been used for many years for its ability to inactivate various viruses, cancer, and acquired immune deficiency syndrome but is now making strides in the treatment of musculoskeletal disorders such as rheumatoid arthritis, lumbar facet joint syndrome, subacromial bursitis, carpal tunnel syndrome, osteoarthritis, hip bursitis, shoulder adhesive capsulitis, herniated disc, and temporomandibular joint disorder.

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          Most cited references79

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          The rising prevalence of chronic low back pain.

          National or state-level estimates on trends in the prevalence of chronic low back pain (LBP) are lacking. The objective of this study was to determine whether the prevalence of chronic LBP and the demographic, health-related, and health care-seeking characteristics of individuals with the condition have changed over the last 14 years. A cross-sectional, telephone survey of a representative sample of North Carolina households was conducted in 1992 and repeated in 2006. A total of 4437 households were contacted in 1992 and 5357 households in 2006 to identify noninstitutionalized adults 21 years or older with chronic (>3 months), impairing LBP or neck pain that limits daily activities. These individuals were interviewed in more detail about their health and health care seeking. The prevalence of chronic, impairing LBP rose significantly over the 14-year interval, from 3.9% (95% confidence interval [CI], 3.4%-4.4%) in 1992 to 10.2% (95% CI, 9.3%-11.0%) in 2006. Increases were seen for all adult age strata, in men and women, and in white and black races. Symptom severity and general health were similar for both years. The proportion of individuals who sought care from a health care provider in the past year increased from 73.1% (95% CI, 65.2%-79.8%) to 84.0% (95% CI, 80.8%-86.8%), while the mean number of visits to all health care providers were similar (19.5 [1992] vs 19.4 [2006]). The prevalence of chronic, impairing LBP has risen significantly in North Carolina, with continuing high levels of disability and health care use. A substantial portion of the rise in LBP care costs over the past 2 decades may be related to this rising prevalence.
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            Scientific and medical aspects of ozone therapy. State of the art.

            V. Bocci (2006)
            The aim of this review is to dispel misconceptions and skepticism regarding ozone therapy and to clarify the biochemical and pharmacological mechanisms of action of ozone dissolved in biological fluids. The work performed in the last decade in our laboratory allows drawing a comprehensive framework for understanding and recommending ozone therapy in some diseases. It is hoped that this report will open a dialogue among clinical scientists and will inform physicians about the beneficial effects of ozone therapy.
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              Osteoarthritis: diagnosis and treatment.

              Osteoarthritis is a common degenerative disorder of the articular cartilage associated with hypertrophic bone changes. Risk factors include genetics, female sex, past trauma, advancing age, and obesity. The diagnosis is based on a history of joint pain worsened by movement, which can lead to disability in activities of daily living. Plain radiography may help in the diagnosis, but laboratory testing usually does not. Pharmacologic treatment should begin with acetaminophen and step up to nonsteroidal anti-inflammatory drugs. Exercise is a useful adjunct to treatment and has been shown to reduce pain and disability. The supplements glucosamine and chondroitin can be used for moderate to severe osteoarthritis when taken in combination. Corticosteroid injections provide inexpensive, short-term (four to eight weeks) relief of osteoarthritic flare-ups of the knee, whereas hyaluronic acid injections are more expensive but can maintain symptom improvement for longer periods. Total joint replacement of the hip, knee, or shoulder is recommended for patients with chronic pain and disability despite maximal medical therapy.
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                Author and article information

                Journal
                Med Gas Res
                Med Gas Res
                MGR
                Medical Gas Research
                Medknow Publications & Media Pvt Ltd (India )
                2045-9912
                Jul-Sep 2018
                25 September 2018
                : 8
                : 3
                : 103-110
                Affiliations
                [1 ]Department of Physiology and Biophysics, Stony Brook University School of Medicine, Stony Brook, NY, USA
                [2 ]Foley Plaza Medical, New York, NY, USA
                [3 ]Medical Student Research Institute, St. George's University School of Medicine, Grenada, West Indies
                [4 ]Department of Urology, Stony Brook University School of Medicine, Stony Brook, NY, USA
                Author notes
                [* ]Correspondence to: Sardar Ali Khan, skysalik@ 123456gmail.com .

                Author contributions

                OS designed, organized, and wrote the review article; designed the outline; solved queries related to scientific publications from the journals. NLS performed Medline searches, aided in writing the review article and critiqued the literature. IR revised the article to add logical reasoning and corrected the literature. JG critiqued and applied logical reasoning to the literature. WJ critiqued and applied logical reasoning to the literature. SAK formulated clinical concepts, reviewed the article, and corrected the reference. All authors have read and approved the manuscript provided.

                Author information
                http://orcid.org/0000-0002-4759-530X
                Article
                MGR-8-103
                10.4103/2045-9912.241075
                6178642
                30319765
                f866a740-c0ac-49ad-8bdb-f08411b9cbaa
                Copyright: © 2018 Medical Gas Research

                This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

                History
                : 30 May 2018
                : 09 August 2018
                Categories
                Review

                Molecular medicine
                oxygen-ozone therapy,osteoarthritis,herniated disc,carpal tunnel syndrome,lumbar facet syndrome,muscle oxygenation,fibromyalgia,cervical disc herniation

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