Spinal Cord Stimulation in Complex Regional Pain Syndrome and Refractory Neuropathic Back and Leg Pain/Failed Back Surgery Syndrome: Results of a Systematic Review and Meta-Analysis
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Abstract
The drive for good quality evidence has highlighted the importance of well-conducted
systematic reviews and meta-analyses that critically evaluate and grade studies for
new or existing therapies. A systematic review and meta-analysis was performed to
review the efficacy, safety, and cost effectiveness of spinal cord stimulation (SCS)
in complex regional pain syndrome (CRPS) and refractory neuropathic back and leg pain/failed
back surgery syndrome (FBSS). The results support the use of SCS in patients with
refractory neuropathic back and leg pain/FBSS (Grade B evidence) and CRPS type I (Grade
A evidence)/type II (Grade D evidence). SCS not only reduces pain, improves quality
of life, reduces analgesic consumption, and allows some patients to return to work,
with minimal significant adverse events, but may also result in significant cost savings
over time.