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      Repair of Retinal Pigment Epithelium and Choriocapillaries after Laser Photocoagulation: Correlations between Scanning Electron, Transmission Electron and Light Microscopy

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          Abstract

          Cell-to-cell interactions between retinal pigment epithelial (RPE) cells and vascular endothelium were examined by scanning electron microscopy, which demonstrates many facets of surface topography. The repair process after laser photocoagulation was characterized by a morphologically heterogeneous population of regenerated RPE cells, including normal-looking cells, macrophage-like cells and large elongated RPE cells. The macrophage-like and normal-looking RPE cells were predominantly seen adjacent to growing new choroidal vessels. Large cells appeared mainly in the vicinity of the extracellular matrix, where no viable new vessels were seen. The observed association between a specific phenotype of regenerated RPE cells and neovascularization may further support the hypothesis that regenerated RPE cells have a dual function, exerting both stimulatory and inhibitory effects on endothelial cells.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1997
          1997
          11 December 2009
          : 29
          : 6
          : 393-404
          Affiliations
          Department of Ophthalmology and aEye Research Laboratory, Anatomy and Structural Biology, Montefiore Medical Center/Albert Einstein College of Medicine Bronx, New York, N.Y., USA
          Article
          268040 Ophthalmic Res 1997;29:393–404
          10.1159/000268040
          9380341
          f8729f37-e571-4cf0-a002-a56140cba42d
          © 1997 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 21 May 1996
          : 21 February 1997
          Page count
          Pages: 12
          Categories
          Original Paper

          Vision sciences,Ophthalmology & Optometry,Pathology
          Retinal pigment epithelium,Regenerated cells,Macrophage-like RPE cells,Repair process

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