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Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance
José F Caro ,
Jerzy W Kolaczynski ,
Mark R Nyce ,
Joanna P Ohannesian ,
Irina Opentanova ,
Warren H Goldman ,
Richard B Lynn ,
Pei-Li Zhang ,
Madhur K Sinha ,
Robert V Considine
July 1996
July 1996
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Abstract
A receptor for leptin has been cloned from the choroid plexus, the site of cerebrospinal-fluid
(CSF) production and the location of the blood/cerebrospinal-fluid barrier. Thus,
this receptor might serve as a transporter for leptin. We have studied leptin concentrations
in serum and (CSF).