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      Calcitonin: From the Determination of Circulating Levels in Various Physiological and Pathological Conditions to the Demonstration of Lymphocyte Receptors

      Hormone Research in Paediatrics

      S. Karger AG

      Bone, Calcitonin, Estrogens, Hyperparathyroidism, Immunoassay, Lymphocyte, Osteoclast, Osteoporosis, Receptor, Thyroid

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          Abstract

          This article summarizes our main findings concerning calcitonin (CT) physiology and pathology. We have devised a simple extraction method of circulating CT that much improves assay sensitivity and specificity for the measurement of the CT monomer. Combining this extraction method with newer immunometric assays permits a sensitive and exclusive measurement of monomeric CT. CT secretory capacity is 4-5 times lower in women than in men, but there is no significant fall in basal or calcium-stimulated CT levels with age. We also found no evidence for CT deficiency in postmenopausal osteoporosis. On the contrary, changes in circulating CT levels appear to be secondary to the changes in bone turnover, whether in postmenopausal osteoporosis, after estrogen replacement therapy or in renal stone formers. We found a marked CT deficiency after thyroidectomy, radioactive iodine treatment and in patients with congenital hypothyroidism or autoimmune primary hypothyroidism. The deleterious effects of CT deficiency on bone mass remain, however, essentially speculative. Lastly, we have found specific and high-affinity CT receptors on normal circulating T-lymphocytes. Their meaning remains to be demonstrated but we have recently found that the osteolytic cytokines IL-1 and IL-6 are able to markedly reduce the number of CT receptors on T-lymphocytes without changing their affinity.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1993
          1993
          03 December 2008
          : 39
          : 3-4
          : 166-170
          Affiliations
          Bone Metabolism Unit, Service de Médecine et Laboratoire d’Investigation Clinique H.J. Tagnon, Institut Jules Bordet, Centre des Tumeurs de I’Université Libre de Bruxelles, Belgique
          Article
          182719 Horm Res 1993;39:166–170
          10.1159/000182719
          8262480
          © 1993 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Belgian Endocrine Society Lecture

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