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      IgA Nephropathy and Reiter’s Syndrome

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          Immunoglobulin A (IgA) nephropathy is the commonest type of primary glomerulonephritis worldwide. It has previously been reported in association with the seronegative spondyloarthropathies (ankylosing spondylitis, Behcet’s syndrome, psoriatic arthritis, Reiter’s syndrome and the postenteritic arthritides). Since this condition was first described in 1968, 5 previous case reports of biopsy-proven IgA nephropathy associated with Reiter’s syndrome have been published in the English-language literature. Here we report 2 more such cases, along with a review of the literature describing the association of IgA nephropathy and a number of other immune-complex-mediated glomerulonephritides with the seronegative spondyloarthropathies.

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          Most cited references 3

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          The immune complex pathogenesis of glomerulonephritis and pulmonary vasculitis in Behçet's disease.

          A kidney and lung biopsy were performed on a patient with active Behçet's disease with renal and pulmonary involvement. Histologic, immunohistochemical and electron microscopic studies of the kidney biopsy specimen revealed a focal segmental necrotizing glomerulonephritis characterized by the presence of numerous subendothelial and occasional intramembranous deposits containing immunoglobulin G (IgG), the third component of complement (C3), the fourth component of complement (C4) and fibrin(ogen). Histologic and immunohistochemical studies of the lung biopsy specimen showed an acute venulitis and septal capillaritis associated with the presence of identical deposits within the walls of affected vessels. Circulating immune complexes were detected in the patient's serum by Raji cell assay. The findings indicate that the glomerulonephritis and pulmonary vasculitis occasionally occurring in Behçet's disease are due to the deposition of circulating antigen-antibody complexes. In addition, they strongly suggest that the majority of the major and minor manifestations of the disease, such as uveitis, cutaneous vasculitis, synovitis and meningoencephalitis, are a result of vascular immune complex deposition.
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            Rapidly progressive glomerulonephritis in Behcet's syndrome

             D. Landwehr (1980)
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              Proliferative glomerulonephritis with crescent formation in behcet's syndrome

               P. Olsson (1980)

                Author and article information

                S. Karger AG
                February 2000
                28 January 2000
                : 84
                : 2
                : 177-182
                aSection on Nephrology, Department of Internal Medicine, and bDepartment of Pathology, Wake Forest University School of Medicine, Winston-Salem, N.C., USA
                45566 Nephron 2000;84:177–182
                © 2000 S. Karger AG, Basel

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                Figures: 2, Tables: 1, References: 28, Pages: 6
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