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      Hepatocellular transport and secretion of biliary phospholipids.

      1
      Seminars in liver disease
      Georg Thieme Verlag KG

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          Abstract

          Recent progress has begun to elucidate molecular and cellular mechanisms whereby bile salts stimulate hepatocellular selection, transport, and biliary secretion of phospholipids, which are enriched (up to 95%) in phosphatidylcholines. This article first summarizes classical observations concerning the molecular structures of biliary phospholipids, as well as the role of bile salts in promoting their secretion into bile. New data are then reviewed and synthesized into a working model for biliary phospholipid secretion. An important feature is that this model is selective for biliary phospholipids and necessitates a largely independent pathway for cholesterol secretion into bile.

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          Author and article information

          Journal
          Semin Liver Dis
          Seminars in liver disease
          Georg Thieme Verlag KG
          0272-8087
          0272-8087
          May 1996
          : 16
          : 2
          Affiliations
          [1 ] Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.
          Article
          10.1055/s-2007-1007231
          8781023
          f890c722-bdc9-452c-a239-005791c621ab
          History

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