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      Biotinylated Cubosomes: A Versatile Tool for Active Targeting and Codelivery of Paclitaxel and a Fluorescein-Based Lipid Dye.

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          Abstract

          The functionalization of cubosomes with biotin is reported here as an alternative method for the preparation of drug delivery systems capable of active targeting specific receptors that are (over)expressed by cancer cells. We describe the design, synthesis, assembly, and characterization of these novel cubosome nanoparticles by small-angle X-ray scattering (SAXS) and dynamic laser light scattering (DLS) and show their application to human adenocarcinoma cell line HeLa. These cubosomes are stabilized and functionalized with a novel, designed biotin-based block copolymer and are able to simultaneously transport paclitaxel, a potent anticancer drug, and a hydrophobic fluorescent dye in the active targeting of cancer cells. Such biotinylated cubosomes are potentially applicable in diagnosis, drug delivery, and monitoring of the therapeutic response for active targeting versus cancer cells.

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          Author and article information

          Journal
          Langmuir
          Langmuir : the ACS journal of surfaces and colloids
          1520-5827
          0743-7463
          Nov 24 2015
          : 31
          : 46
          Affiliations
          [1 ] Department of Chemistry, University of Zürich , Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
          [2 ] Department of Health Science & Technology, ETH Zurich , Schmelzbergstrasse 9, LFO, E23, 8092 Zürich, Switzerland.
          Article
          10.1021/acs.langmuir.5b03469
          26513646
          f8951adf-ab24-4236-a8be-37299cf37472
          History

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