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      Effect of 1α-Hydroxyvitamin D 3 Treatment on Production of Tumor Necrosis Factor-α by Peripheral Blood Mononuclear Cells and on Serum Concentrations of Soluble Tumor Necrosis Factor Receptors in Hemodialysis Patients

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          Abstract

          The effect of 1,25-dihydroxyvitamin D<sub>3</sub> [1,25-(OH)<sub>2</sub>D<sub>3</sub>] deficiency, as well as of replacement therapy with lα-hydroxyvitamin D<sub>3</sub> [1α-(OH)D<sub>3</sub>], on the production of tumor necrosis factor-α (TNF-α) by peripheral blood mononuclear cells (PBMC) and on the serum levels of soluble TNF receptors (sTNFRs) in hemodialysis (HD) patients was investigated. PBMC from HD patients without prior therapy with hydroxylated vitamin D<sub>3</sub> analogs and from normal controls produced similar amounts of TNF-α, either spontaneously or after stimulation with lipopolysaccharide (LPS). After oral administration of 1α-(OH)D<sub>3</sub>, a precursor of 1,25-(OH)<sub>2</sub>D<sub>3</sub>, LPS-induced TNF-α production by PBMC of HD patients was significantly higher than that of HD patients prior to the treatment or of healthy controls. Such treatment did not, however, affect spontaneous TNF-α production by PBMC. Serum concentrations of both soluble TNF receptors [sTNFR-A(p75) and sTNFR-B(p55)] were significantly higher in HD patients than in controls. The ratio of sTNFR-A/sTNFR-B decreased significantly in HD patients following lα-(OH)D<sub>3</sub> therapy. These results suggest that therapy with 1α-hydroxylated vitamin D<sub>3</sub> analogs normally given to HD patients for the management of renal osteodystrophy may also regulate the in vivo activity of TNF-α.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1994
          1994
          16 December 2008
          : 66
          : 3
          : 262-266
          Affiliations
          aDivision of Nephrology, Kaplan Hospital, Rehovot, Israel; bF. Hoffmann-La Roche Ltd., Pharmaceutical Research – New Technologies, Basel, Switzerland; cTeva Pharmaceutical Industries Ltd., Jerusalem, Israel
          Article
          187820 Nephron 1994;66:262–266
          10.1159/000187820
          8190177
          © 1994 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Original Paper

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