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      A voxel-based morphometric study of ageing in 465 normal adult human brains.

      1 , , , ,   ,
      NeuroImage
      Elsevier BV

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          Abstract

          Voxel-based-morphometry (VBM) is a whole-brain, unbiased technique for characterizing regional cerebral volume and tissue concentration differences in structural magnetic resonance images. We describe an optimized method of VBM to examine the effects of age on grey and white matter and CSF in 465 normal adults. Global grey matter volume decreased linearly with age, with a significantly steeper decline in males. Local areas of accelerated loss were observed bilaterally in the insula, superior parietal gyri, central sulci, and cingulate sulci. Areas exhibiting little or no age effect (relative preservation) were noted in the amygdala, hippocampi, and entorhinal cortex. Global white matter did not decline with age, but local areas of relative accelerated loss and preservation were seen. There was no interaction of age with sex for regionally specific effects. These results corroborate previous reports and indicate that VBM is a useful technique for studying structural brain correlates of ageing through life in humans.

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          Author and article information

          Journal
          Neuroimage
          NeuroImage
          Elsevier BV
          1053-8119
          1053-8119
          Jul 2001
          : 14
          : 1 Pt 1
          Affiliations
          [1 ] Wellcome Department of Cognitive Neurology, Institute of Neurology, London, United Kingdom.
          Article
          S1053-8119(01)90786-4
          10.1006/nimg.2001.0786
          11525331
          f8b317ef-7d1c-4aac-8934-c30e245294bf
          History

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