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      Determination of Insulin-Like Growth Factor I in Children: Normal Values and Clinical Use

      Hormone Research in Paediatrics

      S. Karger AG

      Insulin-like Growth Factor I, Children, Normal values, Clinical use

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          Circulating insulin-like growth factor I (IGF-I) levels are stable throughout the day and correlate with pulsatile endogenous growth hormone (GH) secretion. A single measurement of IGF-I may, therefore, provide information on the GH secretory status of an individual. The clinical use of IGF-I determination in the evaluation of short stature in children suspected of GH deficiency will be discussed. Previous methodological problems have now mostly been overcome, and IGF-I can be determined in serum from healthy children, although concentrations exhibit large inter-individual variations relating to age, gender and pubertal maturation. These variations must be taken into account before IGF-I can be evaluated in a clinical situation, and before it can be stated whether a certain value is too low for a given age. The diagnostic sensitivities of IGF-I reported in relation to the outcome of GH provocative testing are variable (47–100%). This variability probably results from the use of different IGF-I assays, IGF-I reference ranges, and different GH testing procedures. When proper IGF-I assays and reference ranges are used, however, IGF-I determination results in valid diagnostic information regarding children exhibiting short stature. Thus, an IGF-I value should always be evaluated together with auxological information and GH testing results before a decision is taken on whether or not to start GH therapy.

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          Author and article information

          Horm Res Paediatr
          Hormone Research in Paediatrics
          S. Karger AG
          17 November 2004
          : 55
          : Suppl 2
          : 94-99
          Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
          63483 Horm Res 2001;55(suppl 2):94–99
          © 2001 S. Karger AG, Basel

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          Page count
          Figures: 2, References: 57, Pages: 6
          Performance in Clinical Practice


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