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      Transient early wheeze and lung function in early childhood associated with chronic obstructive pulmonary disease genes.

      1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 8 , 8 , 3 , 9 , 10

      The Journal of allergy and clinical immunology

      Elsevier BV

      ALSPAC, Avon Longitudinal Study of Parents and Children, COPD, Child, parents and health: lifestyle and genetic constitution, Chronic obstructive pulmonary disease, ETS, Environmental tobacco smoke, FVC, Forced vital capacity, KOALA, OR, Odds ratio, PIAMA, Prevention and Incidence of Asthma and Mite Allergy, RAGE, Receptor for advanced glycation end products, SNP, Single nucleotide polymorphism, TEW, Transient early wheeze, in utero exposure, lung function growth, transient early wheeze

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          Abstract

          It has been hypothesized that a disturbed early lung development underlies the susceptibility to chronic obstructive pulmonary disease (COPD). Little is known about whether subjects genetically predisposed to COPD show their first symptoms or reduced lung function in childhood.

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          Author and article information

          Journal
          J. Allergy Clin. Immunol.
          The Journal of allergy and clinical immunology
          Elsevier BV
          1097-6825
          0091-6749
          Jan 2014
          : 133
          : 1
          Affiliations
          [1 ] Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; GRIAC Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: m.kerkhof@umcg.nl.
          [2 ] Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; GRIAC Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
          [3 ] School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
          [4 ] Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
          [5 ] Institute for Risk Assessment Science, Utrecht University, Utrecht, The Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
          [6 ] Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
          [7 ] Department of Pediatrics, Division of Respiratory Medicine, Erasmus University Medical Center/Sophia Children's Hospital, Rotterdam, The Netherlands.
          [8 ] Department of Epidemiology, Maastricht University School for Public Health and Primary Care CAPHRI, Maastricht, The Netherlands.
          [9 ] Department of Paediatric Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
          [10 ] Department of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
          Article
          S0091-6749(13)00914-7
          10.1016/j.jaci.2013.06.004
          23886569

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