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Hydrogen peroxide induced impairment of endothelial progenitor cell viability is mediated through a FoxO3a dependant mechanism.
Fei Wang
1 ,
Yu-Qiang Wang ,
Qing Cao ,
Jian-Jun Zhang ,
Li-Ya Huang ,
Tian-Tian Sang ,
Fang Liu ,
Shu-Yan Chen
Nov 2013
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Abstract
Increased oxidative stress has been suggested to contribute to the functional impairment of endothelial progenitor cells (EPCs). The Forkhead box O transcription factors (FoxOs) are critical regulators involved in various cellular processes including cell apoptosis. Here, we investigated whether FoxOs are required in oxidative stress induced EPC apoptosis.