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Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial.
J Y Douillard
1 ,
D Cunningham ,
A D Roth ,
M Navarro ,
R D James ,
P Karasek ,
P Jandik ,
T Iveson ,
J Carmichael ,
M Alakl ,
G Gruia ,
L Awad ,
P Rougier
Mar 25 2000
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Abstract
Irinotecan is active against colorectal cancer in patients whose disease is refractory to fluorouracil. We investigated the efficacy of these two agents combined for first-line treatment of metastatic colorectal cancer.