Valproic Acid significantly lowers serum concentrations of olanzapine-an interaction effect comparable with smoking.

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Abstract

Preliminary reports have indicated that valproic acid (VPA) reduces serum concentrations of olanzapine (OLZ). The aim of this study was to investigate the impact of VPA and other antiepileptic drugs (AEDs) on serum concentrations of OLZ and 3 of its major metabolites in a large-scale material of therapeutic drug monitoring samples.

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Journal

Journal ID (iso-abbrev): Ther Drug Monit

Title: Therapeutic drug monitoring

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1536-3694

ISSN (Print): 0163-4356

Publication date (Electronic): Oct 2012

Volume: 34

Issue: 5

Affiliations

[1 ] Center for Psychopharmacology, Diakonhjemmet Hospital, School of Pharmacy, University of Oslo, Oslo, Norway. tore.haslemo@diakonsyk.no

Article

Publisher Item ID: 00007691-201210000-00006

DOI: 10.1097/FTD.0b013e3182693d2a

PubMed ID: 22972535

SO-VID: f902129b-3533-4a1f-990a-157d9ad982c4

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