21
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Total versus hemithyroidectomy for small unilateral papillary thyroid carcinoma

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The correct approach to treat low-risk intrathyroidal papillary thyroid carcinoma (PTC) is controversial. Specific authors advocate unilateral thyroidectomy to minimize perioperative morbidity. The purpose of the present study was to determine an effective treatment strategy for patients with small unilateral papillary thyroid. This was a retrospective comparative analysis of 161 patients with PTC treated between 2001–2010; 60 consecutive patients following hemithyroidectomy and 101 patients following total thyroidectomy. Only patients with preoperatively-predicted localized unilateral disease were included. No between-group difference was identified in the rate of permanent surgical complications. In total, 36 hemithyroidectomy patients (60%) exhibited benign thyroid nodules in the contralateral lobe on preoperative ultrasound; this factor was found to positively correlate with the performance of ≥1 fine needle aspirations (FNAs) during follow-up. In addition, 47 hemithyroidectomy patients (78.3%) were prescribed thyroxine postoperatively. The hemithyroidectomy patients visited the endocrine clinic significantly less frequently than the total thyroidectomy patients (P=0.01), but were referred more often for neck ultrasound (P=0.03) and FNA (P<0.001). In addition, an increased number of patients in the hemithyroidectomy group were reoperated for suspected recurrent/persistent disease (P=0.06). Results of this retrospective study indicate that hemithyroidectomy for small unilateral PTC is associated with a significant follow-up burden and provides no clear patient benefit.

          Related collections

          Most cited references15

          • Record: found
          • Abstract: found
          • Article: not found

          An observation trial without surgical treatment in patients with papillary microcarcinoma of the thyroid.

          The recent prevalence of ultrasound-guided fine-needle aspiration biopsy has resulted in a marked increase in the number of patients with papillary microcarcinoma (maximum diameter,
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Gross and microscopic findings in clinically normal thyroid glands.

              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Thyroid incidentalomas. Prevalence by palpation and ultrasonography.

              S. Ezzat (1994)
              Thyroid nodules are commonly identified on autopsy examination. There are relatively few descriptions, however, of the frequency with which thyroid nodules are encountered incidentally during the course of other investigations. Prospective study to examine the prevalence of thyroid nodules in asymptomatic North American subjects, with palpation findings compared with findings on high-resolution ultrasonography. Palpable nodules were identified in 21 (21%) of 100 subjects, with nine solitary nodules (9%) and 12 multiple nodules (12%). In comparison, only 33 subjects were found to be free of any nodules by ultrasonography. Of the 67 subjects with abnormal ultrasound findings, 22 had solitary nodules (22%) and 45 had multiple nodules (45%). The prevalence of nodules was greater in women (72%) than in men (41%) (P < .02). A concordance rate of 49% was noted between ultrasound and findings by palpation. The data indicate that thyroid abnormalities are very common incidental findings, emphasizing the need for a conservative approach when such lesions are encountered incidentally.
                Bookmark

                Author and article information

                Journal
                Oncol Lett
                Oncol Lett
                OL
                Oncology Letters
                D.A. Spandidos
                1792-1074
                1792-1082
                March 2014
                18 December 2013
                18 December 2013
                : 7
                : 3
                : 849-853
                Affiliations
                [1 ]Institute of Endocrinology, Rabin Medical Center, Beilinson Hospital, Petach Tikva 49100, Israel
                [2 ]Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel
                [3 ]Academic College of Tel Aviv-Yaffo, Tel Aviv 6818211, Israel
                [4 ]Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 6997801, Israel
                Author notes
                Correspondence to: Dr Dania Hirsch, Institute of Endocrinology, Rabin Medical Center, Beilinson Hospital, 39 Jabotinski Street, Petach Tikva 49100, Israel, E-mail: daniaron@ 123456netvision.net.il
                Article
                ol-07-03-0849
                10.3892/ol.2013.1765
                3919925
                24520302
                f923fc03-8016-424e-a3bf-f1018259f746
                Copyright © 2014, Spandidos Publications

                This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

                History
                : 19 May 2013
                : 26 November 2013
                Categories
                Articles

                Oncology & Radiotherapy
                thyroid surgery,thyroid cancer,thyroidectomy,outcome,thyroid
                Oncology & Radiotherapy
                thyroid surgery, thyroid cancer, thyroidectomy, outcome, thyroid

                Comments

                Comment on this article