1
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      TRH synthesis in “mute” thyrotropinomas: cause‐effect or coincidence?

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          In the pathogenesis of thyrotropin (TSH) immunopositive pituitary adenomas, trigger mutagenetic events are well recognized. However, the way towards a clinical significant tumor is followed under the pressure of growth factors, among which the intrapituitary synthesis of releasing factors could bring a significant contribution. In this study, the production of thyrotropin releasing hormone (TRH) and beta TSH chain was evaluated at the mRNA level by in situ hybridization and end product level by immunohistochemistry, in 18 patients submitted to neurosurgery for pituitary macroadenomas. The hormonal sampling showed abnormal secretion for FSH in 5 and TSH in 4 patients. Seven cases were immunopositive for TSH, and expressed TSH β mRNA. All but one out of these expressed also TRH mRNA. FSH immunoreactivity was documented in 12/ 18, only one of these being negative for TRH mRNA. Paracrine TRH could contribute to the patogenesis of these “mute” adenomas.

          Related collections

          Author and article information

          Journal
          J Cell Mol Med
          J. Cell. Mol. Med
          10.1111/(ISSN)1582-4934
          JCMM
          Journal of Cellular and Molecular Medicine
          Blackwell Publishing Ltd (Oxford, UK )
          1582-1838
          1582-4934
          01 May 2007
          January 2001
          : 5
          : 1 ( doiID: 10.1111/jcmm.2001.5.issue-1 )
          : 88-91
          Affiliations
          [ 1 ]“Carol Davila” University of Medicine and Pharmacy, Department of Endocrinology, Bucharest, Romania
          [ 2 ]University of Wales College of Medicine, Department of Medicine, Endocrinology and Metabolism, Cardiff, Heath Park, United Kingdom
          Author notes
          [* ] *Correspondence to: Dr. Corin BADIU “Carol Davila” University of Medicine and Pharmacy, Department of Endocrinology, PO Box 41‐31, 78260 Bucharest, Romania. E‐mail: rpnes@ 123456sunu.rnc.ro
          Article
          PMC6737753 PMC6737753 6737753 JCMM88
          10.1111/j.1582-4934.2001.tb00141.x
          6737753
          12067454
          Page count
          References: 13, Pages: 4
          Categories
          Article
          Custom metadata
          2.0
          January 2001
          Converter:WILEY_ML3GV2_TO_NLMPMC version:5.6.9 mode:remove_FC converted:10.09.2019

          Comments

          Comment on this article