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Insight into the role of HOG pathway components Ssk2p, Pbs2p, and Hog1p in the opportunistic yeast Candida lusitaniae.

Author(s): Bruno da Silva, Nicolas Papon, F Leclerc, Stéphanie Boisnard, Martine Florent, Gwenaël Ruprich-Robert

Publication date: 2008-11-30

Keywords: Candida, enzymology, genetics, physiology, Candidiasis, microbiology, Fungal Proteins, metabolism, Glycerol, Humans, Mitogen-Activated Protein Kinases, Osmolar Concentration, Signal Transduction

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Abstract

In the present study, we have investigated the role of SSK2, PBS2, and HOG1, encoding modules of the high-osmolarity-glycerol mitogen-activated protein kinase pathway in Candida lusitaniae. Functional analysis of mutants indicated that Ssk2p, Pbs2p, and Hog1p are involved in osmotolerance, drug sensitivity, and heavy metal tolerance but not in oxidant stress adaptation.

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PubMed ID:: 18952902

PMC ID:: 2593183

DOI:: 10.1128/EC.00262-08

ScienceOpen disciplines: Chemistry

Keywords: Candida,enzymology,genetics,physiology,Candidiasis,microbiology,Fungal Proteins,metabolism,Glycerol,Humans,Mitogen-Activated Protein Kinases,Osmolar Concentration,Signal Transduction

Insight into the role of HOG pathway components Ssk2p, Pbs2p, and Hog1p in the opportunistic yeast Candida lusitaniae.

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