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      Emergence of macrolide-resistant Streptococcus pyogenes strains in French children.

      Antimicrobial Agents and Chemotherapy

      Anti-Bacterial Agents, Adolescent, pharmacology, Bacterial Proteins, genetics, Child, Child, Preschool, DNA, Bacterial, Drug Resistance, Bacterial, Electrophoresis, Gel, Pulsed-Field, France, epidemiology, Genome, Bacterial, Humans, Macrolides, Membrane Proteins, Methyltransferases, Microbial Sensitivity Tests, Pharyngitis, microbiology, Reverse Transcriptase Polymerase Chain Reaction, Serotyping, Streptococcal Infections, Streptococcus pyogenes, drug effects

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          Abstract

          We studied the antimicrobial susceptibility of 322 Streptococcus pyogenes throat isolates from French children and their serotype and genomic diversity. A total of 22.4% were erythromycin resistant, and 69.4, 4.2, and 26.4% of these isolates harbored ermB, ermA, and mefA, respectively. Increasing resistance in France is mainly associated with a few emm type 28 clones.

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          Author and article information

          Journal
          15328126
          514735
          10.1128/AAC.48.9.3559-3562.2004

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