We describe measurements of the mirror vignetting in the XMM-Newton Observatory made
in-orbit, using observations of SNR G21.5-09 and SNR
3C58 with the EPIC imaging cameras. The instrument features that complicate these
measurements are briefly described. We show the spatial and energy dependences of
measured vignetting, outlining assumptions made in deriving the eventual agreement
between simulation and measurement. Alternate methods to confirm these are described,
including an assessment of source elongation with off-axis angle, the surface brightness
distribution of the diffuse X-ray background, and the consistency of Coma cluster
emission at different position angles. A synthesis of these measurements leads to
a change in the XMM calibration data base, for the optical axis of two of the three
telescopes, by in excess of 1 arcminute. This has a small but measureable effect on
the assumed spectral responses of the cameras for on-axis targets.