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      Enhanced Prostaglandin Synthesis Contributes to the Venoconstrictor Activity of Ergotamine


      Journal of Vascular Research

      S. Karger AG

      Veins, Ergotamine, α-Adrenoceptors, Prostaglandins

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          Spiral strips from dog saphenous veins were contracted by 2.5 × 10<sup>–9</sup> M ergotamine, a concentration giving about 50% of maximal response. Phentolamine (3.6 × 10<sup>–6</sup> m) reduced these effects by 60% and indomethacin (2.8 × 10<sup>–7</sup> m) by 30%. Indomethacin was more effective in reducing ergotamine-induced increase of prostaglandin E-like activity in the bathing fluid than those induced by noradrenaline or potassium chloride. Arachidonic acid was more effective in increasing tension in ergotamine-stimulated than in noradrenaline- or potassium-stimulated veins. These findings suggest that the long-lasting venoconstrictor activity of ergotamine is mediated mainly by α-adrenoceptors but that enhanced formation of prostaglandin E-like substance(s) may also contribute.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          18 September 2008
          : 12
          : 4
          : 193-205
          Biological and Medical Research Division, Sandoz Ltd., Basel
          158056 Blood Vessels 1975;12:193–205
          © 1975 S. Karger AG, Basel

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          Page count
          Pages: 13


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