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      Enhanced Prostaglandin Synthesis Contributes to the Venoconstrictor Activity of Ergotamine

      ,

      Journal of Vascular Research

      S. Karger AG

      Veins, Ergotamine, α-Adrenoceptors, Prostaglandins

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          Abstract

          Spiral strips from dog saphenous veins were contracted by 2.5 × 10<sup>–9</sup> M ergotamine, a concentration giving about 50% of maximal response. Phentolamine (3.6 × 10<sup>–6</sup> m) reduced these effects by 60% and indomethacin (2.8 × 10<sup>–7</sup> m) by 30%. Indomethacin was more effective in reducing ergotamine-induced increase of prostaglandin E-like activity in the bathing fluid than those induced by noradrenaline or potassium chloride. Arachidonic acid was more effective in increasing tension in ergotamine-stimulated than in noradrenaline- or potassium-stimulated veins. These findings suggest that the long-lasting venoconstrictor activity of ergotamine is mediated mainly by α-adrenoceptors but that enhanced formation of prostaglandin E-like substance(s) may also contribute.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1975
          1975
          18 September 2008
          : 12
          : 4
          : 193-205
          Affiliations
          Biological and Medical Research Division, Sandoz Ltd., Basel
          Article
          158056 Blood Vessels 1975;12:193–205
          10.1159/000158056
          © 1975 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 13
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          Paper

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