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Bovine lactoferrin supplementation for prevention of late-onset sepsis in very low-birth-weight neonates: a randomized trial.
Paolo Manzoni
1 ,
Matteo Rinaldi ,
Silvia Cattani ,
Lorenza Pugni ,
Mario Giovanni Romeo ,
Hubert Messner ,
Ilaria Stolfi ,
Lidia Decembrino ,
Nicola Laforgia ,
Federica Vagnarelli ,
Luigi Memo ,
Linda Bordignon ,
Onofrio Sergio Saia ,
Milena Maule ,
Elena Gallo ,
Michael Mostert ,
Cristiana Magnani ,
Michele Quercia ,
Lina Bollani ,
Roberto Pedicino ,
Livia Renzullo ,
Pasqua Betta ,
Fabio Mosca ,
Fabrizio Ferrari ,
Rosario Magaldi ,
Mauro Stronati ,
Daniele Farina
Oct 07 2009
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Abstract
Sepsis is a common and severe complication in premature neonates, particularly those with very low birth weight (VLBW) (<1500 g). Whether lactoferrin, a mammalian milk glycoprotein involved in innate immune host defenses, can reduce the incidence of sepsis is unknown. In animal models, the probiotic Lactobacillus rhamnosus GG (LGG) enhances the activity of lactoferrin but has not been studied in human infants.