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      Time-Dependent Effect of Cyclosporine on Mitogenic Responses and Lymphocyte Subset Populations in Rat Spleen and Submaxillary Lymph Nodes

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          Lipopolysaccharide (LPS)- and concanavalin A (ConA)-induced proliferation and T lymphocyte subsets were measured in spleen and submaxillary lymph nodes of male rats injected with cyclosporine (5 mg/kg s.c. for 5 days, at 12.00 or 24.00 h; animals kept under light from 08.00 to 20.00 h daily). One hour before the third injection, Freund’s complete adjuvant or its vehicle was administered. A suppressive effect of cyclosporine on the mitogenic action of LPS was seen in the spleen of rats injected with cyclosporine at noon whereas the effect of ConA remained unaffected. CD4+, CD8+ and CD4+-CD8+ cells decreased in spleen and lymph nodes of Freund’s adjuvant-injected rats only with cyclosporine given at noon. The results further support occurrence of time-of-day-dependent effects of cyclosporine on lymphocyte subsets and proliferation.

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          Monitoring of Insulin Content During Human Islet Isolation


            Author and article information

            S. Karger AG
            February 1999
            18 February 2000
            : 7
            : 2
            : 84-88
            Departamento de Bioquímica y Biología Molecular III, Facultad de Medicina, Universidad Complutense, Madrid, España, y Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Argentina
            26424 Neuroimmunomodulation 2000;7:84–88
            © 2000 S. Karger AG, Basel

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            Figures: 3, References: 24, Pages: 5
            Original Paper


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