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      Drug Design, Development and Therapy (submit here)

      This international, peer-reviewed Open Access journal by Dove Medical Press focuses on the design and development of drugs, as well as the clinical outcomes, patient safety, and programs targeted at the effective and safe use of medicines. Sign up for email alerts here.

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      A novel curcumin-loaded composite dressing facilitates wound healing due to its natural antioxidant effect

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          Abstract

          Purpose

          To prepare a novel wound dressing to facilitate cutaneous wound healing.

          Methods

          Curcumin (Cur) was added to the ring-shaped β-cyclodextrin (CD) to form a β-CD–Cur inclusion complex (CD-Cur). CD-Cur was then integrated into a composite chitosan–alginate (CA) mix. Finally, CA-CD-Cur was generated with a freeze-drying technique. Water-uptake capacity, degradation rate, and drug-release kinetics of the newly formed dressing were investigated in vitro. In animal studies, cutaneous wounds in rats were created, treated with CA-CD-Cur, then compared to CA-Cur, CA, and gauze.

          Results

          CA-CD-Cur–treated wounds showed accelerated closure rates, improved histopathological results, and lower SOD, lipid peroxidation, pI3K, and pAktkt levels than other groups. On the contrary, catalase, IκBα, and TGFβ 1 levels were higher than others.

          Conclusion

          CA-CD-Cur may facilitate cutaneous wound dressing that facilitate wound healing.

          Most cited references24

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          The in vitro stability and in vivo pharmacokinetics of curcumin prepared as an aqueous nanoparticulate formulation.

          Chandana Mohanty, Sanjeeb K Sahoo (2010)
          Curcumin, the natural anticancer drug and its optimum potential is limited due to lack of solubility in aqueous solvent, degradation at alkaline pH and poor tissue absorption. In order to enhance its potency and improve bioavailability, we have synthesized curcumin loaded nanoparticulate delivery system. Unlike free curcumin, it is readily dispersed in aqueous medium, showing narrow size distribution 192 nm ranges (as observed by microscope) with biocompatibility (confocal studies and TNF-alpha assay). Furthermore, it displayed enhanced stability in phosphate buffer saline by protecting encapsulated curcumin against hydrolysis and biotransformation. Most importantly, nanoparticulate curcumin was comparatively more effective than native curcumin against different cancer cell lines under in vitro condition with time due to enhanced cellular uptake resulting in reduction of cell viability by inducing apoptosis. Molecular basis of apoptosis studied by western blotting revealed blockade of nuclear factor kappa B (NFkappaB) and its regulated gene expression through inhibition of IkappaB kinase and Akt activation. In mice, nanoparticulate curcumin was more bioavailable and had a longer half-life than native curcumin as revealed from pharmacokinetics study. Thus, the results demonstrated nanoparticulate curcumin may be useful as a potential anticancer drug for treatment of various malignant tumors. Copyright (c) 2010 Elsevier Ltd. All rights reserved.
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            Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries.

            Scott L. O’Neill, A Bowie (2000)
            Nuclear factor-kappaB (NFKB) is a transcription factor with a pivotal role in inducing genes involved in physiological processes as well as in the response to injury and infection. A model has been proposed whereby the diverse agents that activate NFkappaB do so by increasing oxidative stress within the cell. Activation of NFkappaB involves the phosphorylation and subsequent degradation of an inhibitory protein, IKB, and recently many of the proximal kinases and adaptor molecules involved in this process have been elucidated. Additionally, we now understand in detail the NFkappaB activation pathway from cell membrane to nucleus for interleukin-1 (IL-1) and tumour necrosis factor (TNF). This review revisits the evidence for the oxidative stress model in light of these recent findings, and finds little in the new information to rationalise or justify a central role for oxidative stress in NF-kappaB activation. We demonstrate that much of the evidence for the involvement of oxidative stress is either specific to a stimulus in a particular cell line or open to reinterpretation. In particular, the activation of NFkappaB by hydrogen peroxide is cell-specific and distinct from physiological activators such as IL-1 and TNF, while inhibition by antioxidants, also found to be cell- and stimulus-specific, can involve diverse and unexpected targets which may be distinct from redox modulation. We conclude that in most cases the role of oxidative stress in NF-kappaB activation is at best facilitatory rather than causal, if a role exists at all. In addition, other evidence suggests a role for lipid peroxides in pathways where such a role exists. In future, when a role for oxidative stress in a pathway is postulated, the challenge will be to show which particular kinases or adaptor molecules, if any, are redox-modulated.
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              Development of curcumin–cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems

              Gautier M.A. Ndong Ntoutoume, Robert Granet, Jean Pierre Mbakidi … (2016)
              The synthesis of curcumin-cyclodextrin/cellulose nanocrystals (CNCx) nano complexes was performed. CNCx were functionalized by ionic association with cationic β-cyclodextrin (CD) and CD/CNCx complexes were used to encapsulate curcumin. Preliminary in vitro results showed that the resulting curcumin-CD/CNCx complexes exerted antiproliferative effect on colorectal and prostatic cancer cell lines, with IC50s lower than that of curcumin alone.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Drug Des Devel Ther
                Journal ID (iso-abbrev): Drug Des Devel Ther
                Journal ID (publisher-id): DDDT
                Journal ID (pmc): dddt
                Title: Drug Design, Development and Therapy
                Publisher: Dove
                ISSN (Electronic): 1177-8881
                Publication date (Electronic): 16 September 2019
                Publication date Collection: 2019
                Volume: 13
                Pages: 3269-3280
                Affiliations
                [1 ]Department of Orthopedic Trauma and Microsurgy, Zhongnan Hospital of Wuhan University , Wuhan 430070, Hubei, People’s Republic of China
                [2 ]Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University , Wuhan, Hubei 430072, People’s Republic of China
                [3 ]Department of Orthopedics, Hubei University of Medicine Affliated Taihe Hospital , Shiyan 442000, Hubei, People’s Republic of China
                Author notes
                Correspondence: Aixi Yu Department of Orthopedic Trauma and Microsurgy, Zhongnan Hospital of Wuhan University , 169 Donghu Road, Wuchang District, Wuhan430070, Hubei, People’s Republic of ChinaTel +86 1 350 718 7489Email yuaixi@whu.edu.cn
                Shiwen Huang Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University , 16 Luojiashan Road, Wuchang District, Wuhan430072, Hubei, People’s Republic of ChinaTel +86 186 2786 5822Email swhuang@whu.edu.cn
                Article
                Publisher ID: 219224
                DOI: 10.2147/DDDT.S219224
                PMC ID: 6754538
                SO-VID: f952d68b-6d81-4f10-9c2f-7b62c3d9b8e6
                Copyright © © 2019 Zhao et al.
                License:

                This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms ( https://www.dovepress.com/terms.php).

                History
                Date received : 12 June 2019
                Date accepted : 07 August 2019
                Page count
                Figures: 7, References: 35, Pages: 12
                Categories
                Subject: Original Research

                ScienceOpen disciplines: Pharmacology & Pharmaceutical medicine
                Keywords: curcumin,cyclodextrin inclusion complex,chitosan,alginate,cutaneous wound healing
                Data availability:
                ScienceOpen disciplines: Pharmacology & Pharmaceutical medicine
                Keywords: curcumin, cyclodextrin inclusion complex, chitosan, alginate, cutaneous wound healing

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