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      Trials and tribulations on the path to developing a dengue vaccine.

      1 , 2

      Vaccine

      Elsevier BV

      Dengue, Immunology, Vaccine

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          Abstract

          Dengue is a rapidly expanding global health problem. Development of a safe and efficacious tetravalent vaccine along with strategic application of vector control activities represents a promising approach to reducing the global disease burden. Although many vaccine development challenges exist, numerous candidates are in clinical development and one has been tested in three clinical endpoint studies. The results of these studies have raised numerous questions about how we measure vaccine immunogenicity and how these readouts are associated with clinical outcomes in vaccine recipients who experience natural infection. In this review the authors discuss the dengue vaccine pipeline, development challenges, the dengue vaccine-immunologic profiling intersection, and research gaps.

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          Author and article information

          Journal
          Vaccine
          Vaccine
          Elsevier BV
          1873-2518
          0264-410X
          Nov 27 2015
          : 33 Suppl 4
          Affiliations
          [1 ] Walter Reed Army Institute of Research, Silver Spring, MD, USA. Electronic address: stephen.j.thomas3.mil@mail.mil.
          [2 ] University of Rhode Island, Providence, RI, USA.
          Article
          S0264-410X(15)00779-3
          10.1016/j.vaccine.2015.05.095
          26122583
          f95615e5-74d3-4337-ae2b-95c8ea535e4b

          Dengue, Immunology, Vaccine

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