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      Effects of hyperimmune equine plasma on clinical and cellular responses in a low-dose endotoxaemia model in horses

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      Research in Veterinary Science

      Elsevier BV

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          Abstract

          Endotoxaemia is a major cause of equine morbidity, and plasma from horses immunised against Escherichia coli is used in its treatment. The aim of this study was to determine the effects of hyperimmune plasma on the clinical and leukocyte responses, including production and activity of TNFα, in an in vivo endotoxin challenge model. Pre-treatment with hyperimmune equine plasma had no significant effect on peak total plasma TNFα concentration (occurring 90min after the administration of 30ng/kg LPS). However, the bioavailable (unbound) TNFα measured by bioassay was significantly reduced in plasma-treated horses (1044.44±193.93pg/ml at 90min) compared to saline treated controls (1373.92±107.63pg/ml; P=0.05). Therefore, although pre-treatment with hyperimmune equine plasma did not significantly modify the clinical signs of endotoxaemia in this model, there was some evidence of reduced TNF bioactivity, which may be due to factors in the plasma which bind and reduce the activity of this cytokine.

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          Author and article information

          Journal
          Research in Veterinary Science
          Research in Veterinary Science
          Elsevier BV
          00345288
          February 2012
          February 2012
          : 92
          : 1
          : 40-44
          Article
          10.1016/j.rvsc.2010.10.020
          21093001
          © 2012

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