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      Peptide identification of hepatocyte growth-promoting factor and its function in cytoprotection and promotion of liver cell proliferation through the JAK2/STAT3/c-MYC pathway

      , , , , , , ,
      European Journal of Pharmacology
      Elsevier BV

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          A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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            Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.

            DAVID bioinformatics resources consists of an integrated biological knowledgebase and analytic tools aimed at systematically extracting biological meaning from large gene/protein lists. This protocol explains how to use DAVID, a high-throughput and integrated data-mining environment, to analyze gene lists derived from high-throughput genomic experiments. The procedure first requires uploading a gene list containing any number of common gene identifiers followed by analysis using one or more text and pathway-mining tools such as gene functional classification, functional annotation chart or clustering and functional annotation table. By following this protocol, investigators are able to gain an in-depth understanding of the biological themes in lists of genes that are enriched in genome-scale studies.
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              Cell cycle, CDKs and cancer: a changing paradigm.

              Tumour-associated cell cycle defects are often mediated by alterations in cyclin-dependent kinase (CDK) activity. Misregulated CDKs induce unscheduled proliferation as well as genomic and chromosomal instability. According to current models, mammalian CDKs are essential for driving each cell cycle phase, so therapeutic strategies that block CDK activity are unlikely to selectively target tumour cells. However, recent genetic evidence has revealed that, whereas CDK1 is required for the cell cycle, interphase CDKs are only essential for proliferation of specialized cells. Emerging evidence suggests that tumour cells may also require specific interphase CDKs for proliferation. Thus, selective CDK inhibition may provide therapeutic benefit against certain human neoplasias.
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                Author and article information

                Contributors
                Journal
                European Journal of Pharmacology
                European Journal of Pharmacology
                Elsevier BV
                00142999
                April 2022
                April 2022
                : 920
                : 174832
                Article
                10.1016/j.ejphar.2022.174832
                35183533
                f9698b04-f8d2-47fe-a0d2-b202c75cf665
                © 2022

                https://www.elsevier.com/tdm/userlicense/1.0/

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