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      Information flow through neural circuits for pheromone orientation.

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          Abstract

          Moths use a sophisticated olfactory navigation strategy for resource localization. Here we investigate the neuronal circuits involved in sensory processing to generate locomotor commands for pheromone-source orientation in the moth. We identify a candidate pathway for pheromone processing in the protocerebrum using a mass-staining technique. Our intracellular recordings of pheromone responsiveness detect four major circuits, including a newly identified unstructured neuropil, the superior medial protocerebrum, which supplies output to the lateral accessory lobe (LAL), the premotor centre for walking commands. Interneurons innervating the lower division of the LAL elicited longer responses than those innervating the upper division. Descending interneurons innervating the lower division of the LAL showed a state-dependent flip-flop response. In contrast, input from other visual areas in the protocerebrum mostly converge onto the upper division of the LAL. These results reveal the basic organization of the LAL: the upper division is identified as a protocerebral hub that receives inputs from various areas, while the lower division generates long-lasting activity for locomotor command.

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          Author and article information

          Journal
          Nat Commun
          Nature communications
          2041-1723
          2041-1723
          2014
          : 5
          Affiliations
          [1 ] 1] Research Center for Advanced Science and Technology, University of Tokyo, Meguro, Tokyo 153-8904, Japan [2] Graduate School of Life and Environmental Sciences, University of Tsukuba, Tennodai, Ibaraki 305-8573, Japan.
          [2 ] Graduate School of Life and Environmental Sciences, University of Tsukuba, Tennodai, Ibaraki 305-8573, Japan.
          [3 ] Graduate School of Information Science and Technology, University of Tokyo, Hongo, Tokyo 113-8656, Japan.
          [4 ] 1] Research Center for Advanced Science and Technology, University of Tokyo, Meguro, Tokyo 153-8904, Japan [2] Graduate School of Information Science and Technology, University of Tokyo, Hongo, Tokyo 113-8656, Japan.
          Article
          ncomms6919
          10.1038/ncomms6919
          25533353
          f969cc7c-f4fc-46a8-b71c-9ff3b8dcaf5e
          History

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