Haemodynamic Effects of Tiapamil and Verapamil in Conscious Rats following Chronic Myocardial Infarction

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Abstract

The haemodynamic effects of the two calcium antagonists, tiapamil and verapamil, were compared in conscious rats with or without myocardial infarction. In control rats without myocardial infarction, verapamil was about 20 times more potent than tiapamil to reduce arterial blood pressure. However, if equihypotensive doses of tiapamil and verapamil were compared, verapamil produced a 2-fold larger decrease of dp/dt<sub>max+</sub> (p < 0.01). Three weeks after myocardial infarction, the negative inotropic effect of both tiapamil and verapamil were potentiated to the same extent. However, if equihypotensive doses of tiapamil and verapamil were compared, tiapamil was still less negative inotropic than verapamil.

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Journal

Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1988

Publication date (Print): 1988

Publication date (Electronic): 11 November 2008

Volume: 75

Issue: 3

Pages: 161-169

Affiliations

Pharmaceutical Research Department, F. Hoffmann-La Roche & Co., Basel, Switzerland

Article

Publisher ID: 174366 Other ID: Cardiology 1988;75:161–169

DOI: 10.1159/000174366

PubMed ID: 3416326

SO-VID: f975e7c8-53e2-4026-bbb7-5aaaac26e6a0

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 26 December 1986

Date accepted : 31 August 1987

Page count

Pages: 9

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