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      Haemodynamic Effects of Tiapamil and Verapamil in Conscious Rats following Chronic Myocardial Infarction

      Cardiology

      S. Karger AG

      Tiapamil, Verapamil, Calcium antagonists, Myocardial infarction

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          Abstract

          The haemodynamic effects of the two calcium antagonists, tiapamil and verapamil, were compared in conscious rats with or without myocardial infarction. In control rats without myocardial infarction, verapamil was about 20 times more potent than tiapamil to reduce arterial blood pressure. However, if equihypotensive doses of tiapamil and verapamil were compared, verapamil produced a 2-fold larger decrease of dp/dt<sub>max+</sub> (p < 0.01). Three weeks after myocardial infarction, the negative inotropic effect of both tiapamil and verapamil were potentiated to the same extent. However, if equihypotensive doses of tiapamil and verapamil were compared, tiapamil was still less negative inotropic than verapamil.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1988
          1988
          11 November 2008
          : 75
          : 3
          : 161-169
          Affiliations
          Pharmaceutical Research Department, F. Hoffmann-La Roche & Co., Basel, Switzerland
          Article
          174366 Cardiology 1988;75:161–169
          10.1159/000174366
          3416326
          © 1988 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 9
          Categories
          Original Paper

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