16
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Endothelial Cell Injury in Cardiovascular Surgery: The Intimal Hyperplastic Response

      ,
      The Annals of Thoracic Surgery
      Elsevier BV

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Arteries and veins respond to injury by a healing process that includes the development of a neointima. This response to injury is implicated as the primary cause of failure after arterial reconstruction. Because it is an integrator and transmitter of blood flow variations, inflammation, and growth stimuli, the endothelium is a potent regulator of long-term arterial wall mass changes. The contribution of the endothelium to intimal development depends on the type of arterial conduit. In arteries, the growth of the intima stops when the endothelium has regrown. In synthetic grafts, the endothelium stabilizes intimal growth. Hence, the mere presence of endothelial cells can influence intimal changes in arterial conduits. Understanding endothelial biology should help us define methods to prevent cell proliferation, extracellular matrix accumulation, intimal hyperplasia, and vessel narrowing.

          Related collections

          Author and article information

          Journal
          The Annals of Thoracic Surgery
          The Annals of Thoracic Surgery
          Elsevier BV
          00034975
          February 1997
          February 1997
          : 63
          : 2
          : 582-591
          Article
          10.1016/S0003-4975(96)01045-4
          9033355
          f985f1f4-5890-4cda-ba05-0e56eb95188d
          © 1997

          https://www.elsevier.com/tdm/userlicense/1.0/

          History

          Comments

          Comment on this article