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      The Pathogenetic Significance of Intravascular Coagulation in Experimental Acute Renal Failure

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          Abstract

          Serum and urine fibrin(ogen) degradation products (FDP), FDP clearances, and serum urea nitrogen (SUN) concentrations of rats challenged with glycerol-induced myohemoglobinuria were measured serially over a period of 4 days. The results obtained in animals that developed acute renal failure (ARF) were compared with those obtained in rats made refractory to renal failure by long-term salt loading or recent recovery from prior renal failure. Only the rats susceptible to ARF experienced a major rise in serum FDP concentration. Urine FDP excretion rose most markedly in the same rats but, being elevated in all groups, showed the utilization of fibrinogen whether serum FDP values increased or not. The results obtained might reflect differences in the degree of intravascular coagulation which are pathogenetically important. It is possible, however, that increased serum FDP concentrations found exclusively in rats with ARF are the results rather than the cause of impaired filtration, and that reduced tubular absorption may at least partly account for the high urinary FDP excretion observed in this model of experimental acute renal failure.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1978
          1978
          02 December 2008
          : 22
          : 4-6
          : 484-491
          Affiliations
          Departments of Medicine, Peter Bent Brigham Hospital and Massachusetts General Hospital, Harvard Medical School; the Newton Wellesley Hospital, Tufts University School of Medicine, Boston, Mass., and the Medical College of Virginia and Veterans Administration Hospital, Richmond, Va.
          Article
          181517 Nephron 1978;22:484–491
          10.1159/000181517
          740111
          © 1978 S. Karger AG, Basel

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          Page count
          Pages: 8
          Categories
          Original Paper

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