Responsiveness of Cortisol and Dehydroepiandrosterone to ACTH in Children

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Abstract

In a total of 101 children, the dehydroepiandrosterone (DHA) and cortisol (F) levels were measured before and after ACTH (Synacten®) administration. F responsiveness was unchanged during development, while DHA responsiveness in healthy children was highest during adrenarche. In hypopituitary patients DHA levels were lower than in the controls, but responsiveness to ACTH showed similar changes during development. Children with Turner’s syndrome and hypergonadotrophic males had the response in elevated DHA levels while ACTH-induced DHA response related to bone-age matched controls. We conclude that regulation of adrenal androgens is mediated by both ACTH and another hypothalamo-pituitary hormone, perhaps independent of gonadal activation, but requiring gonadal integrity.

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Journal ID (publisher-id): HRE

Journal ID (nlm-ta): Horm Res Paediatr

Journal ID (doi): 10.1159/issn.1663-2818

Title: Hormone Research in Paediatrics

Publisher: S. Karger AG

ISSN (Print): 1663-2818

ISSN (Electronic): 1663-2826

Publication date Subscription-year: 1982

Publication date (Print): 1982

Publication date (Electronic): 25 November 2008

Volume: 16

Issue: 1

Pages: 32-41

Affiliations

Department of Diagnostic Endocrinology, University Children’s Hospital, Tübingen, FRG

Article

Publisher ID: 179482 Other ID: Horm Res 1982;16:32–41

DOI: 10.1159/000179482

PubMed ID: 6279482

SO-VID: f987b310-2afa-4b44-8574-33c6301b4a20

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Responsiveness of Cortisol and Dehydroepiandrosterone to ACTH in Children

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Karger: Endocrinology

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