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      Responsiveness of Cortisol and Dehydroepiandrosterone to ACTH in Children

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          Abstract

          In a total of 101 children, the dehydroepiandrosterone (DHA) and cortisol (F) levels were measured before and after ACTH (Synacten®) administration. F responsiveness was unchanged during development, while DHA responsiveness in healthy children was highest during adrenarche. In hypopituitary patients DHA levels were lower than in the controls, but responsiveness to ACTH showed similar changes during development. Children with Turner’s syndrome and hypergonadotrophic males had the response in elevated DHA levels while ACTH-induced DHA response related to bone-age matched controls. We conclude that regulation of adrenal androgens is mediated by both ACTH and another hypothalamo-pituitary hormone, perhaps independent of gonadal activation, but requiring gonadal integrity.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1982
          1982
          25 November 2008
          : 16
          : 1
          : 32-41
          Affiliations
          Department of Diagnostic Endocrinology, University Children’s Hospital, Tübingen, FRG
          Article
          179482 Horm Res 1982;16:32–41
          10.1159/000179482
          6279482
          © 1982 S. Karger AG, Basel

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          Page count
          Pages: 10
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