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      Regulation of Adrenal Cell-Differentiated Functions by Growth Factors

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          Abstract

          Adrenal cell-differentiated functions and, therefore, their steroidogenic capacity can be regulated in an opposite direction by insulin-like growth factor I (IGF-I) and transforming growth factor-β<sub>1</sub> (TGFβ<sub>1</sub>). The enhanced steroidogenic responsiveness of bovine and ovine adrenal cells treated with IGF-I can be explained by its positive effects on the number of corticotropin (ACTH) and angiotensin II (A-II) receptors associated with an increase in the α<sub>s</sub> and α<sub>i</sub> subunits of G proteins but also by its effects on several steps of the steroidogenic pathway. In contrast, TGFβ<sub>1</sub> is a potent inhibitor of differentiated functions of both bovine and ovine adrenal cells. TGFβ<sub>1</sub> reduces ACTH and A-II receptor number, inhibits cAMP formation, and decreases several steroidogenic enzyme activities. The physiological role of these peptides in adrenal cells is strengthened by the fact that both are synthetized and secreted by these cells and that their secretion can be regulated by the specific hormones, ACTH and A-II.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          978-3-8055-6037-5
          978-3-318-00054-2
          1663-2818
          1663-2826
          1994
          1994
          05 December 2008
          : 42
          : 1-2
          : 39-43
          Affiliations
          INSERM U 307 Hôpital Debrousse, Lyon, France
          Article
          184143 Horm Res 1994;42:39–43
          10.1159/000184143
          7959633
          © 1994 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Growth Factors in Endocrinology: Recent Advances, Therapeutic Prospects

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