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      The genetics of inbreeding depression.

      1 ,
      Nature reviews. Genetics
      Springer Science and Business Media LLC

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          Abstract

          Inbreeding depression - the reduced survival and fertility of offspring of related individuals - occurs in wild animal and plant populations as well as in humans, indicating that genetic variation in fitness traits exists in natural populations. Inbreeding depression is important in the evolution of outcrossing mating systems and, because intercrossing inbred strains improves yield (heterosis), which is important in crop breeding, the genetic basis of these effects has been debated since the early twentieth century. Classical genetic studies and modern molecular evolutionary approaches now suggest that inbreeding depression and heterosis are predominantly caused by the presence of recessive deleterious mutations in populations.

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          Author and article information

          Journal
          Nat Rev Genet
          Nature reviews. Genetics
          Springer Science and Business Media LLC
          1471-0064
          1471-0056
          Nov 2009
          : 10
          : 11
          Affiliations
          [1 ] Institute for Evolutionary Biology, Ashworth Laboratories, King's Buildings, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK. deborah.charlesworth@ed.ac.uk
          Article
          nrg2664
          10.1038/nrg2664
          19834483
          f999b390-6d17-4318-9eb7-2c7a5b8f0369
          History

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