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      Effects of xanthine oxidase inhibitors on cardiovascular disease in patients with gout: a cohort study.

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          Abstract

          Hyperuricemia and gout are associated with an increased risk of cardiovascular disease (CVD). It is unknown whether treating hyperuricemia with xanthine oxidase inhibitors (XOIs), including allopurinol and febuxostat, modifies cardiovascular risks.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Am. J. Med.
          Title: The American journal of medicine
          ISSN (Electronic): 1555-7162
          ISSN (Print): 0002-9343
          Publication date (Electronic): Jun 2015
          Volume: 128
          Issue: 6
          Affiliations
          [1 ] Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, Mass; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Mass; Department of Epidemiology, Harvard School of Public Health, Boston, Mass. Electronic address: skim62@partners.org.
          [2 ] Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, Mass; Department of Epidemiology, Harvard School of Public Health, Boston, Mass.
          [3 ] Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, Mass.
          [4 ] Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, Mass; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Mass.
          Article
          Publisher Item ID: S0002-9343(15)00086-8 Mid ID: NIHMS675089
          DOI: 10.1016/j.amjmed.2015.01.013
          PubMed ID: 25660249
          SO-VID: f9c11e90-c372-4fbe-a822-6df0a63f154a
          Copyright © Copyright © 2015 Elsevier Inc. All rights reserved.
          History

          Keywords: Allopurinol,Cardiovascular disease,Febuxostat,Gout,Heart failure,Myocardial infarction,Stroke,Xanthine oxidase inhibitor
          Data availability:
          Keywords: Allopurinol, Cardiovascular disease, Febuxostat, Gout, Heart failure, Myocardial infarction, Stroke, Xanthine oxidase inhibitor

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