Across contemporary Africa, pluralistic medical fields are becoming increasingly complex, giving rise to newly emerging constellations of healing practices and a vast array of therapeutic possibilities. We present portraits of four 'traditional' healers in southern Ghana who selectively adapt, adopt, and modify elements of biomedical, 'local,' and 'exotic' healing practices in eclectic and creative ways, positioning themselves strategically in a highly pluralistic, contested, and globalized medical arena. Their practices are informed by 'traditional' knowledge, passed down through families and acquired through spiritually directed dreams, but also from medical textbooks, Google searches, 'scientific' experimentation, and interactions with the biomedical sector. The healers make use of modern information and communication technologies to increase their geographical reach, and respond to the opportunities and risks of an increasingly global but strongly differentiated therapeutic market. However, while apparently transgressing therapeutic boundaries, they are simultaneously drawing on a discourse of stabilizing and straddling those boundaries to legitimize their practices.