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      CNK/T-cell brain lymphoma associated with Epstein-Barr virus in a patient with AIDS.

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          Abstract

          We report a case of extranodal NK/T-cell lymphoma, nasal type, with exclusive cerebral localization in a patient with AIDS. The patient presented with neurological alterations, fever and convulsions, so the initial presumptive diagnosis was an opportunistic brain infection. MRI showed a left parietal necrotic lesion and a stereotactic brain biopsy was performed for pathological, microbiological and molecular studies. Histological sections showed an angiocentric and angiodestructive growth pattern and the immunophenotype of this tumor was CD56+, CD45+, CD3+ (cytoplasmic), Granzyme B+ and Perforin+. All the microbiological studies such as bacterial, fungi, micobacteria, Toxoplasma gondii and Cryptococcus determination were negatives. A PCR study with primer specific for EBV viral genome of Bam-Hi-w system was positive. Also, a rearrangement study showed T-cell gene rearrangement with monoclonal appearance. A diagnosis of extranodal NK/T-cell lymphoma was made and the patient died a few days later. This case represents a very rare example of NK/T-cell lymphoma of the brain in a patient with AIDS. The diagnosis of this kind of lymphomas requires a multimodality approach correlating clinical, morphological, immunophenotypic and molecular data.

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          Author and article information

          Journal
          Neuropathology
          Neuropathology : official journal of the Japanese Society of Neuropathology
          0919-6544
          0919-6544
          Aug 2007
          : 27
          : 4
          Affiliations
          [1 ] Department of Pathology and Tumor Bank, Infectious Pathology Unit, Hospital Universitario Virgen de las Nieves, Avda Fuerzas Armadas, 2,18014 Granada, Spain. fernando.cobo.sspa@juntadeandalucia.es
          Article
          17899696
          f9dfe555-4a48-4e3f-992e-94b728624a7b
          History

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